81 Results for "

Commiphora mukul (Hook. ex Stocks) Engl.

" in MedChemExpress (MCE) Product Catalog:
Products (81)

81 Results for "Commiphora mukul (Hook. ex Stocks) Engl." in MCE Product Catalog:

21
Guggulsterone
Guggulsterone
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21 Publications Verification
Cat. No.: HY-107738
CAS No.: 95975-55-6
Purity:  99.81%
Synonyms: Z/E-Guggulsterone
Category:  

Triterpenes Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .
6
(Z)-Guggulsterone
(Z)-Guggulsterone
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6 Cited Publications
Cat. No.: HY-110066
CAS No.: 39025-23-5
Purity:  99.30%
Category:  

Commiphora myrrha (Nees) Engl. Plants Burseraceae Disease Research Fields Cancer Steroids

Target:  

Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR

(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .
6
Corynoxeine
Corynoxeine
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6 Cited Publications
Cat. No.: HY-N0590
CAS No.: 630-94-4
Category:  

Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

ERK

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
3
Triptonide
Triptonide
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3 Cited Publications
Cat. No.: HY-32736
CAS No.: 38647-11-9
Synonyms: NSC 165677; PG 492
Category:  

Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Wnt β-catenin Apoptosis Autophagy

Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
3
Corynoxine
Corynoxine
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3 Cited Publications
Cat. No.: HY-N0901
CAS No.: 6877-32-3
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
1
β-Bisabolene
β-Bisabolene
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1 Cited Publications
Cat. No.: HY-136552
CAS No.: 495-61-4
Purity:  97.28%
Category:  

other families Terpenoids Sesquiterpenes Plants Disease Research Fields Cancer

Target:  

Others

β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer .
1
Geissoschizine methyl ether
Geissoschizine methyl ether
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1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
1,3-Dipalmitin
1,3-Dipalmitin
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Cat. No.: HY-128792
CAS No.: 502-52-3
Purity:  ≥99.0%
Synonyms: 1,3-Dipalmitoylglycerol; Glycerol 1,3-dipalmitate
Category:  

Araceae Plants Sauromatum giganteum (Engler) Cusimano & Hetterscheid Lipid

Target:  

Biochemical Assay Reagents

1,3-Dipalmitin (1,3-Dipalmitoylglycerol) is a diacylglycerol compound that can be found in the tuberous roots of Typhonium giganteum Engl. 1,3-Dipalmitin acts as an adsorption inhibitor for 1,3-diglycerides and β-carotene .
Ilexoside D
Ilexoside D
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Cat. No.: HY-N5037
CAS No.: 109008-27-7
Category:  

Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf

Target:  

Others

Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .
Dihydropyrocurzerenone
Dihydropyrocurzerenone
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Cat. No.: HY-N8757
CAS No.: 59462-26-9
Category:  

Commiphora sphaerocarpa Chiov. Terpenoids Sesquiterpenes Plants Burseraceae

Target:  

Others

Dihydropyrocurzerenone is a furanosesquiterpene isolated from the resin of Commiphora sphaerocarpa .
Wilforlide A
Wilforlide A
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Cat. No.: HY-N0476
CAS No.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Category:  

Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Others

Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .
PROTAC Chk1 degrader-1
PROTAC Chk1 degrader-1
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Cat. No.: HY-161108
CAS No.: 2597167-34-3
Target:  

PROTACs Checkpoint Kinase (Chk)

Research Areas:  

Cancer

PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
Leptomerine
Leptomerine
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Cat. No.: HY-N4206
CAS No.: 22048-97-1
Category:  

Alkaloids other families Quinoline Alkaloids Plants

Target:  

Cholinesterase (ChE)

Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity .
Furanogermacra-1(10)Z,4Z-dien-6-one
Furanogermacra-1(10)Z,4Z-dien-6-one
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Cat. No.: HY-N10840
CAS No.: 88010-63-3
Category:  

Commiphora myrrha (Nees) Engl. Terpenoids Sesquiterpenes Plants Burseraceae

Target:  

Others

Furanogermacra-1(10)Z,4Z-dien-6-one is a furanosesquiterpenoid that can be found in Commiphora myrrha .
Laetanine
Laetanine
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Cat. No.: HY-N4307
CAS No.: 72361-67-2
Category:  

Infection Alkaloids Phenols Polyphenols Plants Lauraceae Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.

Target:  

Parasite

Laetanine is a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity. Laetanine can be found in the extract of the leaves of Phoebe tavoyana (Meissn) Hook .
Wilforgine
Wilforgine
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Cat. No.: HY-N1072
CAS No.: 37239-47-7
Category:  

Terpenoids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Calcium Channel

Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system .
STING Degrader-1
STING Degrader-1
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Cat. No.: HY-162331
Target:  

Molecular Glues STING

Research Areas:  

Inflammation/Immunology Cancer

STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
Commiphora mukul extract
Commiphora mukul extract
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Cat. No.: HY-N18774
CAS No.: 93165-11-8
Category:  

Extract

Target:  

Others

Commiphora mukul extract is rich in active ingredients, such as phytosterols, guggul lipids, and guggulsterones (particularly guggulsterones). Commiphora mukul extract can be used in obesity research.
(Z)-Guggulsterone (Standard)
(Z)-Guggulsterone (Standard)
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Cat. No.: HY-110066R
CAS No.: 39025-23-5
Category:  

Commiphora myrrha (Nees) Engl. Plants Burseraceae Steroids

Target:  

Reference Standards Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR

(Z)-Guggulsterone (Standard) is the analytical standard of (Z)-Guggulsterone. This product is intended for research and analytical applications. (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .
Dipalmitin
Dipalmitin
0 Images
Cat. No.: HY-N7399
CAS No.: 26657-95-4
Category:  

Araceae Plants Sauromatum giganteum (Engler) Cusimano & Hetterscheid Lipid

Target:  

Environmental Pollutants

Dipalmitin is an active product that can be extracted from root tuber of Typhonium giganteum Engl. Dipalmitin is a diacylglycerol that contains the saturated 16-carbon fatty acid Palmitic acid (HY-N0830) at two positions .
Assay Types